Synthesis of Coumarin Derivatives and Assessment of their Anti Microbial Activity

V. Narmadhadevi, Dr. Shubashini K. Sripathi

Abstract: A series of iodo and nitro coumarin derivatives have been synthesized and the structures of newly synthesized compounds were confirmed on the basis of IR and CO-IR data. The synthesized compounds were tested for their in vitro antimicrobial activity in a disc diffusion technique and streak plate isolation method against four strains of bacteria and three fungal strains. The tested compounds have shown different activity in terms of growth inhibition of microorganism.

Keywords: Iodo coumarin derivatives, Nitro coumarin derivatives, Disc diffusion technique, Streak plate isolation method, antibacterial activity, and antifungal activity.