Design and Characterization of Diltiazem Hydrochloride Sustained Release Microspheres

Dr. M. Ravi, S. Kavitha, M. S. Riyazullah, V. Ananda Deepak, B. Dwarakesh

Abstract: The main aim of this study is to formulate and evaluate the control release Diltiazem micro capsules. The formulation is carried out using liquid paraffin as dispersion medium and poly-caprolactone as polymer by employing evaporation method. The specific speed, medium LP (ml), and the drug to polymer ratio is 1: 1, 1: 2, 1: 3 and 1: 4 are used for each batch were optimized. The droplet coalescence during stirring was prevented by adding magnesium stearate to the medium and the microspheres are solidified and hardened by using n hexane. Scanning electron microscopy and infrared spectroscopy were employed to understand the characteristics of prepared Diltiazem microspheres like drug loading, compatibility properties and micrometric enumeration. The Phosphate buffer of 7.4 pH was used to perform in-vitro drug release study. Various interpretations were done with the prepared Diltiazem microspheres.

Keywords: Diltiazem microcapsules, microspheres, Liquid paraffin-hexane, scanning electron microscopy