Secure Multi-Tenant UNIX-Based Virtualization for Genomic Data Processing

Sambasiva Rao Madamanchi

Abstract: Genomic data processing demands high-performance computing and stringent data security, especially in multi-institutional clinical and research environments. This study presents a secure, UNIX-based multi-tenant virtualization framework optimized for genomic workflows. By integrating lightweight container technologies with encrypted storage, fine-grained access control, and tenant-aware orchestration, the system enables concurrent execution of complex pipelines without compromising security or performance. It supports industry-standard bioinformatics tools and ensures interoperability across diverse infrastructures, maintaining compliance with regulatory standards such as HIPAA and GDPR. Performance benchmarks demonstrate near-native speeds under high concurrency, with minimal resource overhead. Security evaluations confirm effective tenant isolation, encrypted data handling, and resilience to container escape and unauthorized access. Usability testing shows rapid deployment, efficient scaling, and high end-user satisfaction. This framework offers a robust solution for secure, scalable, and compliant genomic data analysis in collaborative environments.

Keywords: Genomic virtualization, Multi-tenant security, UNIX containers, data privacy compliance