Cytogenetic Toxicity of Magnevist in Stems Cells for Bone Marrow Mice and Finds a Less Toxic Dose for Medical Use

Damyaa Kareem Kadhim

Abstract: This study was established to identify the cytogenetic effect of magnevist of the bone marrow of mice and calculate the dose less toxic and safe for medical use. It was treated with a negative control group 0.2 ml of distilled water. Magnevist was given alone in mice with intraperetonially 0.6 mg / kg for 24 hours and 48 hours. This was considered positive controls. For the treatment groups have given Magnevist alone to mice intraperetonially with 0.4 mg / kg for 24 hours and 48 hours. And given Magnevist to mice intraperetonially with 0.2 mg / kg for 24 hours and 48 hours.. The results showed high induction (P <0.05) of chromosomal aberrations (CAS) and micronuclei (MN) and a decrease in mitotic index (MI) when compared to cationic groups with negative group and positive groups. Interestingly it was observed that the treatment groups were not significant value that low doses with minimal impact on the security of the bone marrow cells.

Keywords: Chromosomal aberrations, Micronuclei, Magnevist. Mitotic index,