Status of Lipid - Peroxidation, Superoxide Dismutase, Ascorbic Acid and Vitamin E in Osteoarthritis Patients

Shweta Dwivedi, Dr. Shreesh Singh, Dr. Geeta Jaiswal

Abstract: Objective: Oxidative stresses are believed to function as primary degenerative mechanism in the development and progression of osteoarthritis. The exact oxidant and antioxidant status in osteoarthritis is not clear. The objectives of our study to evaluate the changes in oxidative stress marker (lipid-peroxidation), antioxidant enzyme (superoxide-dismutase) and non-enzymatic antioxidants in osteoarthritis patients. These patients are also suffering from anemia. Method:-This study was carried out in 100 osteoarthritis and 100 normal individuals are studied. Levels of Lipid-peroxidation were measured by Utley?s method, Superoxide dismutase measured by Marklund?s & Marklund?s method, Ascorbic acid by Carl A Burtis method and vitamin E by Emer Engle method& Blood Hemoglobin by Cyanide method. Result:- Increased blood hemolysate MDA & Superoxide dismutase levels are found in OA as compared to control. Significantly decreased Hb%, Vitamin E & Vitamin C levels found in OA as compared to control. Conclusion: -The result shows increased oxidative stress and decreased non-enzymatic antioxidant in osteoarthritis patients.

Keywords: osteoarthritis, oxidative stress, lipid-peroxidation (MDA), superoxide-dismutase, non-enzymatic antioxidant